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Rory McIlroy and Graeme McDowell turned down the chance to play for Great Britain and Ireland's in next week's Seve Trophy, the biennial event against Europe.
Justin Rose, Luke Donald, Lee Westwood and Ian Poulter will also not travel to Versailles as Sam Torrance's side bid to win the trophy for a seventh successive time against a Europe team skippered by Jose Maria Olazabal.
Instead Torrance's side contains just one member of Europe's successful Ryder Cup team at Medinah last year in Scotland's Paul Lawrie, although three-time Ryder Cup player Paul Casey is included along with fellow Englishmen Tommy Fleetwood, David Lynn, Simon Khan and Chris Wood.
Lawrie is joined by fellow Scots Marc Warren, Stephen Gallacher and Scott Jamieson, with Welshman Jamie Donaldson completing the 10-man team.
Ryder Cup captain Paul McGinley, who appointed Torrance and Olazabal, said: "I'm not too disheartened they're not coming over. I've seen those six players. I know what they can do.
Debrief
"I am interested in attending the debrief with Sam and Jose Maria over a glass of French red wine, interested to hear what they have to say as to how the guys moulded in."
Olazabal's side features three players he led to victory at Medinah in Belgian Nicolas Colsaerts, Swede Peter Hanson and Italian Francesco Molinari, as well as two of his vice-captains, Denmark's Thomas Bjorn and Spaniard Miguel Angel Jimenez.
They will be joined by Finland's Mikko Ilonen and Italian Matteo Manassero, along with rookies Gregory Bourdy, Joost Luiten and Thorbjorn Olesen.
Olazabal, who was also captain in 2005, said: "I think we have a very strong team this year with a good mix of players with Ryder Cup experience and some exciting, talented younger players such as Matteo, Joost and Thorbjorn.
"It is a tournament and a competition that was very close to Seve's heart and we will have to show some of his fighting spirit to win this year and improve on our recent record."